Share This Article:
![](https://www.workerscompensation.com/wp-content/uploads/2024/08/Cameron-Hannum.jpg)
By: Cameron Hannum, Pharm.D., Sr. Clinical Account Pharmacist
Managing chronic pain with medications can be difficult for various reasons. Pain experiences and treatment effectiveness may differ among individuals and caregivers. There are many available analgesic (pain-relieving) medications with wide ranging indications for use, differing safety and efficacy profiles, a fast-changing regulatory environment, and overlapping disease conditions that contribute to the challenge of delivering safe and effective relief for those with chronic pain conditions. According to a pain study conducted in 2016 among adults in the United States, an estimated 20.4% (50 million) suffer with chronic pain and 8% (19.6 million) have high-impact chronic pain which frequently limits life or work activities.
Oral medications are a longstanding standard of care for the management of pain, but they also carry serious risks associated with “whole body” (systemic) exposure to drugs administered by this route. For example, Acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids all have risks when administered orally that are serious and well documented. On the promise of delivering equal or greater efficacy and reducing the risk of adverse events, alternate routes of drug delivery and formulations have been developed.
Topical administration of medication offers an alternative to oral drugs for a smaller number of approved uses. They are locally applied to an affected body area or joint on the skin surface and may be freer of side effects due to their limited distribution in the body.
The effectiveness of a topical medication depends on the penetration of the active ingredient through the dermal barrier. A variety of formulations for application to the surface of the skin or a mucus membrane are available. Prescription and over-the-counter (OTC) versions of creams, lotions, ointments, gels, suspensions, foams, powders and aerosols offer differences in the extent of dermal occlusion (penetration of the active ingredient) and cosmetic acceptability. Other patient and product factors may influence the amount of active ingredient delivered across the skin, including skin thickness, skin barrier status, occlusion, active ingredient molecule size, fat solubility and concentration in the preparation.
Active ingredients commonly incorporated in topical products include local anesthetics (e.g., lidocaine), NSAIDs (e.g., diclofenac), and counterirritants (e.g., capsaicin, menthol, camphor, methyl salicylate and others). Some topicals incorporate carrier molecules like dimethylsulfoxide (DMSO), which increase skin penetration and resulting tissue concentrations.
In general, the advantages of topical analgesics might include:
- A lower risk of systemic adverse events, side effects and drug interactions
- A lower dose of active ingredient may be used to achieve a local effect
- Reduced potential for disruption of gut flora or function
- Ease of administration in pill averse, dysphagic, very elderly or young patients
The disadvantages would be:
- Potential for chemical or allergic irritation (contact dermatitis)
- Insufficient or variable penetration of active ingredient at affected area
- Systemic absorption and related side effects
- Messy, time consuming or inconvenient to apply
The Official Disability Guidelines (ODG) and other expert pain treatment guidelines recognize the appropriate use of some topical analgesics as an option in pain management, based on the targeted condition, body site, available evidence for effectiveness and duration of use. The cost of custom compounded or private-label topical products can be significantly greater than similar, competing OTC, or prescription topicals, and are the subject of regular formulary review along with prior authorization alerts and messaging for PBM program participating clients.
About the Author
Cameron is a Senior Clinical Pharmacist for Enlyte Pharmacy Solutions. In his role, he serves in a client-facing capacity as part of the pharmacy benefit Management (PBM) team and is responsible for supporting and partnering with insurers, third-party administrators and direct employers in developing and operationalizing strategic pharmacy initiatives for their clinical programs. Cameron has large retail chain pharmacy experience, and he has worked the past 6+ years within the workers' comp PBM industry.
Cameron is also a regular contributor to the Ask the Pharmacist Series where this article originally appeared.
www.mitchell.com/ask-the-pharmacist
References:
AI california case management case management focus claims compensability compliance compliance corner courts covid do you know the rule ethics exclusive remedy florida glossary check Healthcare health care hr homeroom iowa leadership medical medicare NCCI new jersey new york ohio opioids osha pennsylvania Safety state info technology tennessee texas violence washington WDYT west virginia what do you think women's history month workers' comp 101 workers' recovery workers' compensation contact information Workplace Safety Workplace Violence
Read Also
About The Author
About The Author
- Cameron Hannum
More by This Author
- Dec 06, 2023
- Cameron Hannum
- Jun 01, 2023
- Cameron Hannum
Read More
- Sep 11, 2024
- Lainey Haynes
- Sep 10, 2024
- John Alchemy Avery Steffen
- Sep 02, 2024
- Nicole Usher
- Aug 25, 2024
- James Moore
- Aug 25, 2024
- NCCI